Long-Term Humoral Immune Response In Persons With Asymptomatic Or Mild Sars-Cov-2 Infection, Vietnam

Huynh Kim Mai,Nguyen Bao Trieu,Trinh Hoang Long,Hoang Tien Thanh,Nguyen Dinh Luong,Le Xuan Huy,Lam Anh Nguyet,Dinh Nguyen Huy Man,Danielle E Anderson,Tran Tan Thanh,Nguyen Van Vinh Chau,Guy Thwaites,Lin-Fa Wang,Le Van Tan,Do Thai Hung

EMERGING INFECTIOUS DISEASES（2021）

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摘要

Antibody response against nucleocapsid and spike proteins of SARS-CoV-2 in 11 persons with mild or asymptomatic infection rapidly increased after infection. At weeks 18-30 after diagnosis, all remained seropositive but spike protein-targeting antibody titers declined. These data may be useful for vaccine development.

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关键词

COVID-19,SARS-CoV-2,SARS-CoV-2 spike protein,asymptomatic coronavirus disease,immune response,neutralizing antibodies,respiratory infections,viruses

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