DNA methylation within genes of microRNA MIR-10B and transcription factor TWIST1 in atherosclerosis

A.V. Markov,N.P. Babushkina,M.V. Golubenko, R.R. Salakhov,D.V. Sharysh,A.A. Zarubin, E.F. Muslimova,S.A. Afanasiev, V.P. Puzyrev, M.S. Nazarenko

Atherosclerosis（2020）

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摘要

Background and Aims: MiR-10b plays a significant role in atherosclerotic plaque formation and is regulated by TWIST transcription factor. Inhibition of miR-10b led to development of atherosclerosis-resistant phenotype and stabilized advanced lesions in mice. We analyzed DNA methylation within MIR10B and TWIST1 genes in tissue samples of patients and healthy individuals to assess epigenetic state of these loci in atherosclerosis.

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Transcriptional Regulation

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