Synthesis Of Proline Analogues Via Rh-Catalyzed Asymmetric Conjugate Addition
ACS CATALYSIS(2021)
摘要
An enantio- and diastereoselective Rh-catalyzed conjugate addition reaction for the synthesis of proline analogues is reported. A high-throughput experimentation campaign was used to identify an efficient chiral catalyst which was able to afford the desired products in high yield and with high levels of diastereo- and enantioselectivity. This method was used to afford a range of 3-substituted proline derivatives from readily available dehydroproline electrophiles and boronic acid nucleophiles.
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关键词
rhodium, 1,4-addition, high-throughput experimentation, proline, unnatural amino acids
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