3d-Printed Cartridge System For In-Flow Photo-Oxygenation Of 7-Aminothienopyridinones

A 3D-printed polypropylene (PP) continuous-photoflow cell based on a modular cartridge system was developed for the photo-oxygenation of 7-aminothieno[3,2-c]pyridin-4(5H)-ones, using ambient air as the sole co-reactant. This strategy takes advantage of the versatility of 3D-printing to construct cost-effective meso-scale reactors. In addition to scalability, a short residence time (t(R) 2 min) in 100-W blue LED light that minimizes the formation of dark, insoluble decomposition products is a tangible benefit of this technology. (C) 2020 Elsevier Ltd. All rights reserved.