Clonal Evolution In Cll

Simon Bouzy,Marine Armand,Clementine Gabillaud,Elise Chapiro,Nadia Bougacha,Fotini Kostopoulou,Frederic Davi,Magali Le Garff-Tavernier,Karim Maloum,Veronique Leblond,Veronique Morel,Damien Roos-Weil,Anne Lavaud,Jean Gabarre,Choquet Sylvain,Santos Susin,Olivier Bernard,Florence Nguyen-Khac

BLOOD（2017）

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摘要

CLL has a heterogeneous genetic landscape, and is characterized by recurrent structural abnormalities. In the era of personalized medicine, it is important to understand the role of clonal and subclonal abnormalities, their dynamic evolution and their impact on disease relapse.

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