A multifunctional Streptomyces maritimus SACC-152 isolated from Andaman and Nicobar Islands, India.

A mangrove derived Streptomyces strain SACC-152 isolated from Andaman and Nicobar Islands was\r\ninvestigated for its multiple bioactive and biosynthetic properties. Morphology, cultural, physiological\r\nand molecular studies showed that the strain SACC-152 is closely similar to Streptomyces maritimus.\r\nBioactive metabolites from the strain SACC-152 were produced by submerged fermentation and\r\nextracted using ethyl acetate. The ethyl acetate extract of strain SACC-152 exhibited a broad spectrum\r\nof antimicrobial activity against various bacterial and fungal pathogens. Luciferase Reporter Phage\r\n(LRP) assay showed more than 80% inhibition against Mycobacterium tuberculosis H37Rv, drug\r\nsensitive and multi drug resistant (MDR) M. tuberculosis strains. In MTT assay, the extract showed\r\npromising activity against HT-29 colon cancer cell lines with the IC50 value of 9.68