Tcr Transgenic Mice: A Valuable Tool For Studying Viral Immunopathogenesis Mechanisms
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES(2020)
摘要
Viral infectious diseases are a significant burden on public health and the global economy, and new viral threats emerge continuously. Since CD4(+) and CD8(+) T cell responses are essential to eliminating viruses, it is important to understand the underlying mechanisms of anti-viral T cell-mediated immunopathogenesis during viral infections. Remarkable progress in transgenic (Tg) techniques has enabled scientists to more readily understand the mechanisms of viral pathogenesis. T cell receptor (TCR) Tg mice are extremely useful in studying T cell-mediated immune responses because the majority of T cells in these mice express specific TCRs for partner antigens. In this review, we discuss the important studies utilizing TCR Tg mice to unveil underlying mechanisms of T cell-mediated immunopathogenesis during viral infections.
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关键词
TCR transgenic mice, immunopathogenesis, viral infection, T cell
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