Bioactive three-dimensional silk composite in vitro tumoroid model for high throughput screening of anticancer drugs

Deepika Arora,Bibhas K Bhunia,G Janani,Biman B Mandal

Journal of Colloid and Interface Science（2021）

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摘要

Schematic representation of different in vitro drug screening platforms. In comparison to monolayer (2D) and 3D spheroids, tunable bio-active silk composite-assisted 3D culture facilitates autonomous remodeling of tumor cells that closely mimic in vivo nativity.

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关键词

Silk composite,3D tumoroid,Metastasis,Stemness,Preclinical model,Drug screening

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