2-Fluoro-5-Nitrophenyldiazonium: A Novel Sanger-Type Reagent For The Versatile Functionalization Of Alcohols
CHEMISTRY-A EUROPEAN JOURNAL(2021)
摘要
As a novel Sanger-type reagent, 2-fluoro-5-nitrophenyldiazonium tetrafluoroborate enabled the versatile functionalization of primary and secondary aliphatic alcohols. Based on a mild nucleophilic aromatic substitution of the fluorine atom under unprecedented, base-free conditions, the diazonium unit on the aromatic core of the resulting aryl-alkyl ether could be employed for such diverse transformations as radical C-H activation and cyclization, as well as palladium catalyzed cross-coupling reactions.
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关键词
C−, C bond formation, C−, H activation, diazonium, nucleophilic aromatic substitution, Sanger reagent
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