Silatrane-containing poly(beta-amino esters)

A series of poly(beta-amino esters) were synthesized using the Michael addition reaction from 1-(3-aminopropyl)silatrane and glycol diacrylates. The structure of the resulting olygomers was confirmed by means of(1)H NMR spectroscopy. Using acetylsalicylic acid as a model drug, the ability of synthesized olygomers to bind carboxyl-containing physiologically active compounds was shown. Synthesized polymers have been found to possess biological activity characteristic of low molecular 1-(3-aminopropyl)silatrane.