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Therapeutic Targeting Of Transcriptional Elongation In Diffuse Intrinsic Pontine Glioma

Hiroaki Katagi,Nozomu Takata,Yuki Aoi,Yongzhan Zhang,Emily J Rendleman,Gavin T Blyth,Frank D Eckerdt,Yusuke Tomita,Takahiro Sasaki,Amanda M Saratsis,Akihide Kondo,Stewart Goldman,Oren J Becher,Edwin Smith,Lihua Zou,Ali Shilatifard,Rintaro Hashizume

NEURO-ONCOLOGY（2020）

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摘要
SEC disruption by KL-1 increased therapeutic benefit in vitro and in vivo, supporting a potential therapeutic activity of KL-1 in H3K27M-mutant DIPG.
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关键词
H3K27M-mutant DIPG,RNA polymerase II (Pol II),patient-derived xenograft (PDX),super elongation complex (SEC),transcriptional elongation
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