Generation of antimicrobial peptides Leg1 and Leg2 from chickpea storage protein, active against food spoilage bacteria and foodborne pathogens

Food Chemistry(2021)

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摘要
•Virtual screening identified 21 antimicrobial peptide candidates from chickpea.•Leg1 and Leg2 exhibit strong bacteriostatic and bactericidal activity.•Both were active against 16 pathogens, antibiotic-resistant and spoilage bacteria.•10–1,000 fold higher activity compared to conventional preservatives.•Atomistic MD simulation indicates specific interaction with the bacterial membrane.
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关键词
AMP,LC–ESI–QTOF-MS/MS,UHPLC,OD,MIC,MBC,MD,DMPE,DMPC,PMF,COM
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