Fatal pyrrolizidine alkaloid poisoning of infants caused by adulterated Senecio coronatus

F J Van Schalkwyk,M A Stander, M Nsizwane, A Mathee,B-E Van Wyk

Forensic Science International（2021）

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摘要

•Senecio coronatus (izonkozonko, ubulibazi) is a popular Zulu paediatric medicine.•It is a traditional enema used for purification of infants during weaning.•The study revealed that this species does not contain pyrrolizidine alkaloids.•Infant fatalities were caused by a Senecio species rich in retrorsine-N-oxide.•A sensitive UPLC-MS/MS method was used for detecting trace amounts of PA.

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关键词

Senecio coronatus,LCMS,UPLC-MS/MS,Retrorsine-N-oxide,Pyrrolizidine alkaloids,Traditional medicine

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