GPR10 gene deletion in mice increases basal neuronal activity, disturbs insulin sensitivity and alters lipid homeostasis

Veronika Pražienková,Jiří Funda,Zdenko Pirník,Alena Karnošová,Lucie Hrubá,Lucia Kořínková,Barbora Neprašová,Petra Janovská, Michal Benzce,Michaela Kadlecová,Jaroslav Blahoš,Jan Kopecký,Blanka Železná,Jaroslav Kuneš,Kristina Bardová,Lenka Maletínská

Gene（2021）

引用 9|浏览8

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摘要

•GPR10 deletion activates PrRP signaling in the NTS regulating energy balance.•Mild obesity with increased adipose tissue and liver weight in GPR10 KO males.•Lipogenesis genes in adipose tissue and liver are downregulated in GPR10 KO males.•Metabolic lipolytic genes are upregulated in GPR10 KO females.•Compensatory expression prevents adipose tissue and liver weight gain in females.

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关键词

Acaca,AMPK,AgRP,BAT,BST,b2M,BW,Cart,Cd36,CNS,CREB,CRH,DAB,Dgat1,Dgat2,DMN,EE,ERK,Fabp4,Fasn,FI,FSH,Gapdh,GH,Gk,gWAT,HFD,HOMA-IR,HR,IHC,JAK/STAT3,KO,LH,MAP,MAPK,Mlxipl,NEFA,NPFF,NPFFR2,Nrf1,NTS,OGTT,ON,PB,Pck2,PDK,PEVN,PFA,PI3K,PKC,POMC,Pparα,Pparγ,Pparγc-1a,Ppib,PRL,PrRP,Gpr10,PVN,RQ,Scd1,scWAT,SEM,Slc2a4,SOCS3,Srebf1,STD,TAG,TRN,TSH,UCP-1,WT,WB

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