Immunogene expression analysis in betanodavirus infected-Senegalese sole using an OpenArray® platform

•Design of an OpenArray® platform to study Senegalese sole transcriptomic response to infection.•The highly virulent NNV induces the highest and earliest transcriptomic response.•Exacerbated IFN-1 response could provoke immunopathology in sole mainly through apoptosis.•rtp3, sacs and isg15 are the most transcribed immunogenes after NNV infection in sole.•Mutations in the NNVcapsid alter viral recognition by the host cells.