Heat hypersensitivity is attenuated with altered expression level of spinal astrocytes after sciatic nerve injury in TRPV1 knockout mice

Kazuhiko Baba,Makoto Kawasaki,Haruki Nishimura,Hitoshi Suzuki,Takanori Matsuura,Teruaki Fujitani,Manabu Tsukamoto,Kotaro Tokuda,Yoshiaki Yamanaka,Hideo Ohnishi,Mitsuhiro Yoshimura,Takashi Maruyama,Kenya Sanada,Hiromichi Ueno,Satomi Sonoda,Kazuaki Nishimura,Kentaro Tanaka,Yoichi Ueta,Akinori Sakai

Neuroscience Research（2021）

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摘要

•Heat sensitivity was attenuated in TRPV1 knockout mice after partial sciatic nerve ligation.•Astrogliosis was impaired in TRPV1 knockout mice after partial sciatic nerve injury.•Chemical inhibition of astrocytes induced heat hyposensitivity.•TRPV1 was co-localized in astrocytic GFAP positive cells in the spinal dorsal horn.•TRPV1 may modulate heat sensitivity via spinal astrogliosis.

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关键词

ANOVA,DRG,GFAP,TRP,TRPV

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