Antimicrobial Effect And Physical Properties Of An Injectable "Active Oxygen" Gel For The Treatment Of Periodontitis

Purpose: To evaluate an injectable gel, recently proposed for the controlled release of "active oxygen" in periodontal pockets, compared to an antibiotic or an antiseptic gel, respectively. Methods: The antimicrobial activity, injectability, texture properties, swelling and water uptake of the gels were studied. Results: The "active oxygen" gel showed a bactericidal effect comparable to the two commercially available drug products (containing minocycline or chlorhexidine) on anaerobic periodontal pathogens and did not seem to affect aerobic strains. The gel was easy to inject and stable in an aqueous medium for several days. Texture analysis revealed potential gel fragility.