Hispolon inhibits RANKL induced osteoclast differentiation in vitro

Dinesh Thimmuri,Shantanu P A,Syamprasad N P, Aasiya Khan,Basveshwar Gawali,Bishal Rajdev, Chanakya Adhikari,Ravichandiran V,Pawan Sharma,Vgm Naidu

Immunology Letters（2021）

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摘要

•Hispolon is a bioactive fungal compound isolated form Phellinus, widely used in oriental medicine for various clinical complications.•Hispolon significantly inhibited the RANKL-induced osteoclastogenesis without any cytotoxicity.•Hispolon inhibited the RANKL-induced osteoclastogenesis through inhibition of NF-KB and MAPK signaling and subsequent inhibition of c-FOS and NFATc1.

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关键词

Hispolon,RANKL,RAW264.7,Osteoclastogenesis,Bone resorption

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