DNA damage-triggered activation of cGAS-STING pathway induces apoptosis in human keratinocyte HaCaT cells (vol 131 ,6222, 2021)

Can Li,Weiwei Liu,Fang Wang,Toshihiko Hayashi,Kazunori Mizuno,Shunji Hattori,Hitomi Fujisaki,Takashi Ikejima

MOLECULAR IMMUNOLOGY（2023）

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摘要

•UVB or cisplatin induces nuclear and mitochondrial DNA damages.•UVB or cisplatin activates cGAS-STING pathway.•STING knockdown inhibits apoptosis caused by UVB or cisplatin.•cGAS-STING activates NF-κB and IRF3-IFNβ pathway leading to apoptosis.

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关键词

UVB,cGAS,cGAMP,STING,TBK1,IRF3,PAMPs,DAMPs,IFNβ,NF-κB,FBS,PARP,IκB,si-NC,si-STING,CBP/P300

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