Design And Synthesis Of An Anthranyl Bridged Optically Active Dinuclear Iron (Ii)-Ligand And Evaluation Of Dna-Cleaving Activity

It is necessary to design a ligand that is compatible with the target molecule to optimally use the DNA-cleaving ability of metal complexes. In this study, we synthesized an optically active dinuclear ligand, (1R,1'R,2R,2'R)-N-1, N-1'- -(anthracene-1,8-diylbis(methylene))bis(N-2,N-2-bis(pyridin-2-ylmethyl)cyclohexane-1,2-diamine) (R-ABDC, 4a) and its enantiomer (S-ABDC, 4b). We then prepared their Fe(II) complexes by mixing the ligand with FeS-O-4 center dot 7H(2)O in situ and investigated DNA-cleaving activities using plasmid DNA in the presence of excess sodium ascorbate at atmospheric conditions. The Fe(II) complexes efficiently cleaved DNA and selectively recognized two consecutive A and/or T sequences.