Liposomes Encapsulating Neoantigens And Black Phosphorus Quantum Dots For Enhancing Photothermal Immunotherapy
JOURNAL OF BIOMEDICAL NANOTECHNOLOGY(2020)
摘要
Colorectal cancer frustrates with high relapse after the traditional treatment including surgery and chemotherapy. Neoantigen-based therapeutic vaccine has achieved high response rate in the clinical trials rising the immunotherapy as a promising alternative for colorectal cancer. Herein, colon cancer cells derived neoantigen peptide Adpgk were employed to be co-encapsulated with black phosphorus quantum dots into liposome (Adpgk-BPQDs-liposome) as therapeutic vaccine. Adpgk-BPQDs-liposome were dispersed in F127 gel containing GM-CSF. The heat generated by black phosphorus (BP) under 808 nm near-infrared laser irradiation accelerates the F127 gel ablation and the release of GM-CSF, which recruit APC cells and prime the native T cells. The tumor bearing mice received the programmed cell death protein 1 (PD-1) checkpoint blockade antibody combined with photo-thermal gel intensively prevented the tumor progress. Furthermore, the tumor infiltrating CD8(+) T cells were significantly increased which lead to the elimination of the tumor.
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关键词
Neoantigen, Black Phosphorous, Immunotherapy, Photothermal, Colon Cancer
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