Could cilostazol be beneficial in COVID-19 treatment? Thinking about phosphodiesterase-3 as a therapeutic target

Nadia Alice Vieira Motta,Lis Jappour Autran,Stephani Correia Brazão,Rosane de Oliveira Lopes,Christianne Brêtas Vieira Scaramello,Gabriel Ferreira Lima,Fernanda Carla Ferreira de Brito

International immunopharmacology（2021）

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摘要

•Cilostazol as adjuvant in the treatment of COVID-19.•Hyperinflammation and coagulability state contribute to COVID-19 severity.•Cilostazol as a multi-target drug for the treatment of COVID-19.•Drug repurposing to address an urgent clinical demand is highlighted.•Cilostazol could play an important role in the treatment of COVID-19.

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关键词

COVID-19,SARS-CoV-2,Cilostazol,Cytokine storm,Anti-inflammatory,Cardioprotective

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