The number of anti-seizure medications mediates the relationship between cognitive performance and quality of life in temporal lobe epilepsy

•Epitrack total score significantly contributes to better QOL composite score.•Epitrack total score contributes to perceived energy and cognitive self-rating.•The number of ASMs mediates the relationship between cognitive deficits and QOL.•The DDD of ASMs does not mediate the association between cognition and QOL.