Apparent Diffusion Coefficient Values Of Cryptorchid Testes And Malignant Transformation Of Cryptorchidism (Mtc) (Seminoma) In Postpubertal Patients

Objectives: Diffusion-weighted imaging signal contrast can be quantified by apparent diffusion coefficient (ADC) maps, which reflect the diffusion properties of the examined tissue and are helpful for identifying pathology. To determine ADC values of cryptorchid testes in post-pubertal patients and assess performance for characterizing cryptorchid testes.Methods: The medical records from 35 patients with unilateral scrotal vacuity were retrospectively reviewed. Data were analyzed in three groups: Group A, normal testes (i.e. the contralateral testes of the patients with cryptorchidism or MTC); Group B, cryptorchid testes; and Group C, malignant transformation of cryptorchidism (MTC) (seminoma). DWI used b-values of 0 and 800 s/mm(2). Mean ADC values were compared using the independent samples t-test. The ability of ADC values was assessed using receiver operating characteristic curve analysis. The sensitivity, specificity, and accuracy were calculated.Results: Mean ADC values for normal testes, cryptorchid testes, and MTC were 1.18 +/- 0.18x10(-3) mm(2)/s, 1.82 +/- 0.40x10(-3) mm(2)/s, and 0.80 +/- 0.06x10(-3) mm(2)/s, respectively. There were statistically significant differences in mean ADC values between normal testes and cryptorchid testes or MTC (p < 0.001). The cut-off ADC value for differentiating normal testes from cryptorchid testes was 1.47 x 10(-3) mm(2)/s. The sensitivity, specificity, and accuracy were 88%, 91%, and 90%, respectively. The cut-off ADC value for differentiating normal testes from MTC was 1.22 x 10(-3) mm(2)/s. The sensitivity, specificity, and accuracy were 100%, 31%, and 43%, respectively.Conclusion: ADC values of cryptorchid testes may be used to inform clinical decision-making and also monitor testicular function in patients who retain undescended testicles or post-operatively.Advances in knowledge: Mean ADC values of cryptorchidism and MTC (seminoma) were used to reflect their pathological features.