Salivary duct carcinoma arising in pleomorphic adenoma

Carcinoma ex pleomorphic adenoma (CPA) is an epithelial and/or myoepithelial malignancy developing from primary or recurrent pleomorphic adenoma. Salivary duct carcinoma is a rare aggressive malignancy of the salivary gland resembling mammary ductal carcinoma, which can occur as a component of CPA. It is a high-grade tumor with poor prognosis. Treatment modalities include surgery and postoperative (adjuvant) radiation therapy. Here, we present an old female patient with a submandibular mass which proved to be salivary duct CPA.