White Matter Injury In A Thromboxane Analog-Induced Model Of Intrauterine Growth Restriction

OBJECTIVE: To determine if the Thromboxane A2 analog model of Intrauterine Growth Restriction or postnatal hyperoxia exposure causes loss of oligodendroglia. DESIGN/METHODS: Pregnant C57Bl6 mice were implanted with micro-osmotic pumps containing Thromboxane A2 analog (U-46619) or 0.5% EtOH at E12.5. After spontaneous birth, pups were cross-fostered until sacrificed at P14 or P28. Pups weighing \u003c 10th percentile at birth were considered to have intrauterine growth restriction (IUGR). Separate groups of vehicle and IUGR pups were placed into 75% FiO2 or room air from birth to P14. The brains …