Synthesis of Vixotrigine, a Voltage- and Use-Dependent Sodium Channel Blocker. Part 2: Development of a Late-Stage Process
Robbie Chen, Vincent Couming,John Guzowski,Erwin Irdam,William F. Kiesman,Daw-Iong Albert Kwok,Wenli Liang,Tamera Mack,Erin M. O'Brien,Suzanne M. Opalka,Daniel Patience, Stefan Sahli,Donald G. Walker,Frederick Osei-Yeboah, Chaozhan Gu,Xin Zhang, Markus Stockli, Thiemo Stucki, Hanspeter Matzinger, Roman Kuhn, Michael Thut, Markus Grohmann, Benjamin Haefner, Joerg Lotz, Michael Nonnenmacher, Paolangelo Cerea Organic Process Research & Development（2020）
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flow chemistry,telescoped reactions,wet milling,manufacturing process
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