N-Of-1 Trial Of A Statin, Placebo, Or No Treatment To Assess Side Effects

Frances A. Wood,James P. Howard,Judith A. Finegold,Alexandra N. Nowbar,David M. Thompson,Ahran D. Arnold,Christopher A. Rajkumar,Susan Connolly,Jaimini Cegla,Chris Stride,Peter Sever,Christine Norton,Simon A.M. Thom,Matthew J. Shun-Shin,Darrel P. Francis

NEW ENGLAND JOURNAL OF MEDICINE（2020）

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摘要

Patients who had discontinued statins because of side effects received four bottles of a statin, four bottles of placebo, and four empty bottles, each to be used for 1 month in a random sequence for 12 months. The symptom burden with placebo was 90% of the symptom burden with the statin.

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