Effectiveness of Vortioxetine on Emotional Blunting in Patients with Major Depressive Disorder with inadequate response to SSRI/SNRI treatment

•About 50% of MDD patients treated with SSRIs or SNRIs suffer emotional blunting•Emotional blunting has important functional consequences for patients’ daily life•In this study vortioxetine was effective for treating emotional blunting•Improvement in emotional blunting correlated with improved overall functioning•Improved emotional blunting also correlated with greater motivation and energy