Troponin T I79n Mutation Causes Ca-Dependent Action Potential Triangulation In Human Induced Pluripotent Stem Cell Model Of Hypertrophic Cardiomyopathy

Lili Wang,Kyungsoo Kim,Shan Parikh,Adrian Gabriel Cadar,Kevin R. Bersell,Huan He,Jose R. Pinto,Dmytro Kryshtal,Bjorn C. Knollmann

Circulation（2017）

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摘要

Background: Mutations in cardiac troponin T (TnT) are linked to a high risk for ventricular arrhythmia and sudden death despite causing little or no cardiac hypertrophy. Studies in mice suggest tha...

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Myofilaments, Cardiomyopathy, Electrophysiology

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