Abstract 14698: Matrix Stiffening Induces a Pathogenic Qki-microrna-7-srsf1 Axis in Pulmonary Arterial Endothelial Cells

Chen-shan J Woodcock,Neha Hafeez,Adam Handen,Ying Tang,Leonard Estephan,Gil Speyer,Seungchan Kim,Thomas Bertero,Stephen Y Chan

Circulation（2020）

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摘要

Introduction: Early increases in pulmonary artery stiffness drive pathogenic alterations of pulmonary arterial endothelial cells (PAECs), leading to vascular remodeling, a prominent feature of pulm...

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