The Novel Late Sodium Current Blocker Gs-458967 Suppresses Action Potential Duration Alternans And Early Afterdepolarization In A Transgenic Rabbit Model Of Long Qt Syndrome Type 2

Jungmin Hwang,Luiz Belardinelli,Sridharan Rajamani,Zachary Pfeiffer,Bryant Yang,Taeyun Kim,Jason Centracchio,Lorraine Schofield,Xuwen Peng,Konstantinos Kodssidas,Gideon Koren,Bum Rak Choi

Circulation（2012）

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摘要

Congenital long QT syndrome type 2 (LQT2) is a familial disease, characterized by prolongation of the QT interval and sudden cardiac death caused by polymorphic ventricular tachycardia (PVT) due to...

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关键词

Sodium channel, Potasslum channel, Triggerng mechansms, Ventricular tachycardia, Electrophyslology

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