Two New Meroterpenes With Activity Against Diacylglycerol Acyltransferase From Seeds Of Psoralea Corylifolia

Two new meroterpenes, 7 beta, 13 beta-Psoracorylifol B (1) and 7 beta, 8 alpha-Psoracorylifol D (3) together with eight known compounds (2, 4 - 10) were isolated from the seeds of Psoralea corylifolia L. They were identified by a series of spectroscopic methods to determine their structures and all the compounds were evaluated for in vitro inhibitory activity against DGAT1/2. Among them, compounds 1-5 and 10 showed moderate inhibitory activity against DGAT1 with IC50 values ranging from 67.1 +/- 1.3-130.4 +/- 1.2 mu M, compounds 1-2 showed weak inhibitory activity against DGAT2 with IC50 values 132.9 +/- 1.1 and 134.2 +/- 1.2 mu M.