Late Breaking Abstract - Relationship Between Obesity And Aging Of The Pulmonary Parenchyma

Introduction: Aging lung decrease in pulmonary functions is related to age. Lung volumes and capacities are reduced particularly the forced expiratory volume in one second (FEV1) and the forced vital capacity (FVC). Male sex, tobacco, high blood pressure and heart diseases can accelerate this decline in lung function as well. The aim of this study is to consider obesity as one of these factors and to highlight its impact in aging of the pulmonary parenchyma. Methods: Our study is retrospective and comparative. We included Male patients aged≥ 65 years who did not smoke for at least one year. Patients with respiratory disease were excluded. Our population was divided into two groups: G1: patients with a body mass index (BMI) <30 kg / m² and G2: patients with a BMI≥30kg/m²). The study consists in comparing respiratory parameters as well as the pulmonary age calculated according to the following formula [2.87 * height- (31.25 * FEV1) -39.375] Results: Twenty-two patients were included. G1 included 12 patients and G2 included 10 patients. Age and size were comparable: age(years) (G1: 74,7; G2: 73,7); size(m) (G1: 166,3; G2: 162,5). The average of BMI was 24.5 kg / m² in G1 and 32.7 kg / m² in G2. The average of FEV1 was higher in G1: FEV1(L) (G1 :2,29; G2: 2,02). The average of the FVC was higher in G1: FVC(L) (G1: 3,17; G2: 2,88) and the average of the inspiratory capacity was higher in G2(IC) (G1: 2,11; G2 :2,41). The average of lung age was significantly lower in G2 (G1 :85,64; G2 :137,3; p=0,001) Conclusion: Obesity is a factor that significantly accelerates the decline in respiratory function and the aging of the pulmonary parenchyma.