Chemical proteomics reveals ligustilide targets SMAD3, inhibiting collagen synthesis in aortic endothelial cells

Wei Lei,Fukui Shen,Nianwei Chang,Lin Niu,Yuanyuan Hou,Boli Zhang,Min Jiang,Gang Bai

Chinese Chemical Letters（2021）

引用 7|浏览65

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摘要

A ligustilide-derived photoaffinity labelling probe combined with chemical proteomics study suggested that Lig targets SMAD3, then blocking TGF-β/SMAD3 signaling and preventing vascular fibrosis.

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关键词

Ligustilide,SMAD3,Collagen synthesis,Chemical proteomics,Photoaffinity labelling

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