Integrative Transcriptome And Quantitative Proteome Analyses Identify Mettl3 As A Key Regulator For Aberrant Rna Processing In Chronic Lymphocytic Leukemia

Yiming Wu,Meiling Jin,Kevyn Hart,Aijun Liao,Stacey M. Fernandes,Tinisha McDonald, Lucy Brown,Daniel Roeth,Markus Kalkum,Raju Pillai,Jianjun Chen,Jennifer R Brown,Steven T. Rosen,Tanya Siddiqi,Lili Wang

BLOOD（2020）

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摘要

Aberrant mRNA processing is known to drive the pathogenesis of chronic lymphocytic leukemia (CLL). Recurrent gene mutations in the RNA splicing factor SF3B1 and widespread RNA intronic polyadenylation impact genome-wide gene expression and inactivate tumor suppressors, respectively. Nevertheless, how mRNA processing is regulated and exerts its function in CLL remain elusive.

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