Hypercoagulability In Patients With Stable Copd Assessed By Coagulation Factor Levels

Background: COPD is associated with increased risk of VTE and atherothrombosis. Objectives: We investigated whether levels of D-dimers and various coagulation factors (F) in patients with stable COPD, are different from those found in healthy individuals and examined potential associations of those coagulation factors among COPD patients. Methods: 103 outpatients with stable COPD and 42 smokers of more than 10-pack-years without airway obstruction (control group) were included. Results: Cardiovascular risk, assessed by HEART score, was not different between COPD and control group (P=0.061). The following markers and coagulation factors were significantly greater in COPD compared to the control group (mean±standard deviation): D-dimers:0.54±0.94 vs. 0.29±0.14ng/mL,p=0.001. FII: 122±22vs.109 ±19%,p= 0.004. FVIII:143±32 vs. 122±20%,p In the COPD group, FII levels were different among GOLD FEV1 stages (p Conclusions: The present study provides evidence for the presence of hypercoagulability in COPD patients and shows that lower lung function, disease progression and history of exacerbations are associated with augmented prothrombotic state.