Comprehensive Characterization Of The Epigenetic Landscape In Multiple Myeloma

Elina Alaterre,Laurie Herviou,Hugues De Boussac,Giorgio Papadopoulos,Stéphanie Boireau,Nicolas Robert,Guilhem Requirand,Angelique Bruyer,Sara Ovejero-Merino,Laure Vincent,Anne Marie Martinez,Giacomo Cavalli,Jerome Moreaux

BLOOD（2020）

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摘要

Multiple myeloma (MM) is a B cell neoplasia characterized by the accumulation of clonal plasma cells within the bone marrow. Epigenetic modifications, including DNA methylation and histone post-translational changes, are involved in MM development and progression, but also in drug resistance.

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