Genome And Transcriptome Profiling Of Monosomy 7 Aml Defines Novel Risk And Therapeutic Cohorts
BLOOD(2020)
摘要
Monosomy 7 (mono7) alterations in acute myeloid leukemia (AML) are associated with poor outcome and disease progression. Through advancements in multi-omic approaches, more specific treatment strategies may be available for high-risk cohorts. Here we describe pediatric cases of AML with mono7, co-occurring fusions, associated outcome, and potential therapeutic treatments.
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