Synthesis and Evaluation of the Cytotoxicity of Indeno[1,2- c ]Isoquinoline Derivatives Bearing Ester Functional Group and 1,2,3-Triazole Moiety

Synthesis of novel indeno[1,2- c ]isoquinoline derivatives, functionalized at the D ring and bearing 1,2,3-triazole unit, has been reported. These hybrid compounds display cytotoxic activity against two human cancer cell lines – KB and HepG2 with half maximal inhibitory concentration (IC 50 ) values in a range of 20–40 μM.