Polyphenolics in ramontchi protect cardiac tissues via suppressing isoprenaline-induced oxidative stress and inflammatory responses in Long-Evans rats

Noushin Akter,Faizul Islam Chowdhury,Saima Selim,Shariful Islam Nayan,Ferdous Khan,Nusrat Subhan,Hemayet Hossain,Mizanur Rahman,Md. Areeful Haque,Ashraful Alam

Journal of Functional Foods（2020）

引用 8|浏览10

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摘要

•HPLC analysis revealed the presence of potent polyphenolics in ramontchi.•Polyphenolics in ramontchi impede cardiac damages in Long-Evans rats.•Ramontchi normalized expressions of antioxidant genes i.e., Nrf-2, HO-1, HO-2, GPx, SOD and CAT.•Ramontchi suppressed the expressions of inflammatory mediators i.e., IL-1, IL-6, TNF-α, TGF-β1, iNOS and NF-κB.•Ramontchi diminished the level of oxidative stress in isoprenaline-induced rats.

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关键词

Polyphenols,Ramontchi,Cardioprotective effect,Inflammatory genes,NF-κB,Antioxidant enzymes

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