Antileishmanial and pharmacophore modeling of abietane-type diterpenoids extracted from the roots of Salvia hydrangea

•Four abietane-type diterpenoids were isolated and identified from roots of Salvia hydrangea.•Antileishmanial activity of purified compounds was tested against the promastigotes of leishmania major.•The cytotoxicity of the plant's root extract was assessed against two human cancer cell lines, MCF-7 and MOLT-4.•A pharmacophore modeling study for antileishmanial activity was carried out.