APOL1 Risk Variants Impair Multiple Mitochondrial Pathways in a Metabolomics Analysis.

Lijun Ma,Nicholette D Palmer,Young A Choi,Mariana Murea,James A Snipes,John S Parks,Carl D Langefeld,Barry I Freedman

Kidney360（2020）

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摘要

Impairment of mitochondrial membrane respiratory chain complex I appeared to account for critical metabolic consequences of KRVs. This finding supports depletion of the mitochondrial membrane potential, as has been reported.

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关键词

APOL1,African Americans,CKD,FSGS,chronic kidney disease,genetics,kidney,metabolomics,mitochondria

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