Pharmacological screening of self-emulsifying drug delivery system containing cyclosporine for solubility enhancement

In the current research, Self-Emulsifying Drug Delivery system (SEDDS) for Cyclosporine is developed and evaluated for feasibility of oral administration. The objective behind the research was to increase the solubility of cyclosporine through Self Emulsifying Drug Delivery System that will increase the bioavailability and reduce the side effects of the drug. The SEDDS was prepared by hot homogenisation method and evaluated for droplet size, zeta potential, polydispersity index, drug loading, in-vitro study and in-vivo study. In-vivo studies for cyclosporine loaded self-emulsifying drug delivery system were carried out in albino rats and the pharmacokinetic parameters i.e. Cmax, T1/2, AUC, Vd were compared with a marketed formulation, which indicated better results of the prepared formulation than the marketed one. So it is concluded that self-emulsifying drug delivery system hold potential as a drug delivery system for drug with poor aqueous solubility.