Chromatographic Analysis of General Otc Anti-Allergic Drug: Cetirizine

Cetirizine as general OTC anti-allergic drug was evaluated through paper chromatography. Twelve cetirizine\r\ncompositions were analysed wherein each tablet and syrups were six in number. Seven solvent systems\r\nwere experimented from which chloroform and methanol in ratio 50:50 proved to be best solvent system\r\nfor both cetirizine tablet and syrup compositions. Other solvent system that showed clear separation of\r\nspots were n-hexane, toluene and diethyl ether in ratio 65:25:10 and acetone and methanol in ratio 90:10 for\r\ntablet and syrup preparations respectively. Iodine fuming technique and UV radiations were also utilized for\r\nvisualising some unidentified and invisible spots during the examination procedures.