Lynch Syndrome and Breast Cancer: Case Reports and Literature Review

In the era of advanced cancer genomics, our knowledge of hereditary cancer mutations continues to expand.\r\nLynch syndrome is one of the hereditary cancer predisposition syndromes associated with an increased\r\nlifelong risk of several types of cancer development, such as colorectal, endometrial, ovarian and other. This\r\nunique syndrome is an autosomal dominant inherited disease caused by mutations on EPCAM gene or on\r\nmismatch repair genes, which lead to microsatellite instability. In this article we will present three such\r\ncases visiting our clinic. They had breast cancer and a familial or personal history of malignancy. This article\r\nsummarizes what we consider important about Lynch syndrome and breast cancer.