Behavior of gallium-68 incorporated in NODA aminoglucose in laboratory animals with various pathological processes

Comparative results of the study of the biological distribution of 68 Ga incorporated in NODA aminoglucose in mice organs and tissues with the experimental model of malignant tumor and aseptic inflammation are presented. It is revealed that pathological conditions have no significant effect on the 68 Ga-NODA aminoglucose behavior after intravenous administration. The dynamics of activity accumulation and excretion in most organs and tissues had no significant differences. The level of activity accumulation in tumor and muscular tissue with inflammation at 1 h after injection of 68 Ga-NODA-aminoglucose exceeded the same values in other organs and tissues, except kidneys. The obtained results show the promising application of 68Ga-NODA- aminoglucose for imaging pathological lesions by positron emission tomography.