Dynamics Of Human Immunodeficiency Virus-1 Genetic Diversification During Acute Infection

Hongshuo Song,Meera Bose,Suteeraporn Pinyakorn,Eric Sanders-Buell,Anne Marie O’Sullivan,Daniel Silas,Rapee Trichavaroj,Bessara Nuntapinit,Phuc T Pham,Siriwat Akapirat,Eugène Kroon,Mark de Souza,Robert Gramzinski,Nelson L Michael,Merlin L Robb,Sandhya Vasan,Sodsai Tovanabutra,Jintanat Ananworanich

OPEN FORUM INFECTIOUS DISEASES（2020）

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摘要

We analyzed human immunodeficiency virus envelope diversity in 98 acute infections. The within-host genetic diversity, divergence from transmitted/founder (T/F) strain, and the observed frequency of multiple TIP infections increased with Fiebig stage. These data identify rapid viral dynamics during acute infection with implications for clinical trials conducted in this setting.

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关键词

acute HIV infection, Fiebig stage, genetic diversity, HIV

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