Endogenous sulfur dioxide is a novel inhibitor of hypoxia-induced mast cell degranulation

Lulu Zhang,Hongfang Jin,Yunjia Song,Selena Ying Chen,Yi Wang,Yan Sun,Chaoshu Tang,Junbao Du,Yaqian Huang

Journal of Advanced Research（2021）

引用 12|浏览28

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摘要

Endogenous sulfur dioxide is a novel inhibitor of hypoxia-induced mast cell degranulation. Endogenous SO2/AAT pathway exists in MCs. Mast cell-derived SO2 upregulates cAMP level through activation of AC and inhibition of PDE, thereby suppressing degranulation of MCs.

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关键词

Endogenous sulfur dioxide,Mast cells,Stabilization,Degranulation,cAMP

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