Effect of curcumin on hemato-biochemical alterations after induced E. coli infection in broilers

Ninety birds were divided into six groups randomly and equally. Group I was normal control, Group II was E. coli control, Group III and IV received curcumin prophylactically and therapeutically @ 200 mg/kg and 400 mg/kg feed, respectively. Group V received cephalexin and Group VI served as curcumin control. From the results of hemato-biochemical profile, significant (P\u003c 0.05) alterations were observed in MCV, MCH, TEC and TLC in E. coli challenged groups compared to controls. Total serum protein levels of curcumin treated groups increased significantly (P\u003c 0.05) compared to E. coli control group. The significant (P\u003c 0.05) alterations in serum AST, ALT, ALP and uric acid levels were observed in E. coli control group. However, these alterations were found to be ameliorated by curcumin treated groups. The average of sodium and potassium values were found to be non-significant whereas serum chloride of E. coil challenged groups increased significantly (P\u003c 0.05) when compared to controls. From the results, it is concluded that curcumin found to have ameliorative effect on altered heamto-biochemical profile in E. coli induced broilers.